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[Dynamics of left ventricular longitudinal function in patients with arterial hypertension during therapy with

E N Pavliukova, T A Bakhmet'eva, K V Puzyrev

    Kardiologiia
    |October 19, 2006
    PubMed

    Insights

    Long-term therapy with moexipril and hydrochlorothiazide improved left ventricular (LV) systolic and diastolic function in patients with arterial hypertension and LV hypertrophy (LVH). This treatment led to significant improvements in myocardial mass and cardiac function parameters.

    Area of Science:

    • Cardiology
    • Hypertension Research
    • Echocardiography

    Context:

    • Arterial hypertension frequently leads to left ventricular hypertrophy (LVH).
    • Angiotensin-converting enzyme (ACE) inhibitors are a cornerstone in managing hypertension and its cardiac complications.
    • Assessing the impact of ACE inhibitor therapy on LV function post-LVH regression is crucial for understanding long-term cardiovascular outcomes.

    Purpose:

    • To evaluate the effects of long-term moexipril and hydrochlorothiazide therapy on left ventricular (LV) longitudinal systolic and diastolic function.
    • To assess functional changes in patients with arterial hypertension following regression of LV hypertrophy (LVH).

    Summary:

    • A study involving 44 hypertensive patients with regressed LVH after 12 months of moexipril and hydrochlorothiazide therapy utilized tissue Doppler imaging and 24-hour blood pressure monitoring.
    • Treatment resulted in decreased myocardial mass and improved 24-hour blood pressure monitoring parameters.
    • Significant improvements were observed in diastolic function, indicated by decreased isovolumetric relaxation time (IVRT) and increased early diastolic mitral annular velocity (e'). Systolic function also showed improvement in several LV segments.

    Impact:

    • Demonstrates that ACE inhibitor and diuretic combination therapy can reverse detrimental cardiac remodeling in hypertensive patients.
    • Highlights the restoration of both systolic and diastolic function following LVH regression.
    • Provides evidence for the beneficial effects of combined therapy on cardiac mechanics and blood pressure control.
    Abstract

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