Screening for motility-associated genes in malignant astrocytoma cell lines
Hyang-Hwa Ryu1, Shin Jung, Heung-Suk Sun
1Brain Tumor Research Laboratory, Medical School, Chonnam National University, Gwangju, and Department of Neurosurgery, Chonnam National University Hwasun Hospital, Jeollanam-do, Republic of Korea.
Abstract:
The most characteristic feature of a malignant astrocytoma is its early and extensive infiltration into adjacent parenchymal structures. We focused on detecting the possible expression changes as the determining factors for malignant astrocytoma's motile ability. We confirmed that four of 39 genes showed different expression on DD-PCR by RT-PCR and Northern blot analysis. These findings suggest that the genes identified may be important for determining high motility in astrocytoma cell lines. These findings may help us understand the molecular invasion mechanism in astrocytomas.
