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Sequencing-by-hybridization revisited: the analog-spectrum proposal

Franco P Preparata1

  • 1Computer Science Department, Brown University, 115 Waterman Street, Providence, RI 02912-1910, USA. franco@cs.brown.edu

IEEE/ACM Transactions on Computational Biology and Bioinformatics
|October 20, 2006
PubMed
Summary

This study introduces an analog-spectrum model for DNA sequencing by hybridization (SBH), moving beyond unrealistic digital models. This new approach enhances sequence reconstruction accuracy by better reflecting biochemical hybridization realities.

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