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Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains

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Nanotechnologies in protein delivery.

Stefano Salmaso¹, Sara Bersani, Alessandra Semenzato

¹Department of Pharmaceutical Sciences, University of Padua, Via F Marzolo, 5-35131 Padua, Italy.

Journal of Nanoscience and Nanotechnology

|October 20, 2006

Summary

Biotechnology and nanotechnology advancements drive the development of novel protein and peptide drug delivery systems. Pharmaceutical nanotechnology offers innovative nanosized formulations for improved therapeutic outcomes and patient compliance.

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Area of Science:

Biopharmaceutical technology
Nanotechnology applications in drug delivery
Protein and peptide therapeutics

Background:

Biotechnology has significantly expanded the range of therapeutic proteins and peptides.
Effective delivery systems are crucial for the clinical success of these biologics.
Current limitations necessitate advanced delivery solutions for enhanced efficacy and patient experience.

Purpose of the Study:

To highlight the critical role of innovative delivery systems for protein and peptide drugs.
To emphasize the potential of pharmaceutical nanotechnology in creating advanced drug formulations.
To underscore the need for collaboration in developing next-generation drug delivery technologies.

Main Methods:

Exploration of colloidal formulations for protein delivery.
Application of pharmaceutical nanotechnology for designing nanosized dosage forms.
Investigation of novel materials and production procedures for drug delivery systems.

Main Results:

Nanosized dosage forms, including nanoparticles and bioconjugates, show promise for drug delivery.
Colloidal formulations possess suitable physicochemical and biopharmaceutical properties for protein delivery.
Tailor-made delivery systems can be designed based on drug properties.

Conclusions:

Pharmaceutical nanotechnology is key to overcoming challenges in protein and peptide drug delivery.
Advanced delivery systems are essential for improving bioavailability, stability, and patient compliance.
Interdisciplinary collaboration is vital for advancing innovative drug delivery solutions.