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[Effect of glaucocalyxin A on level of Th1/Th2 type cytokines in mice]
Zi-jun Chen1, Yun-sen Li, Ji-yan Zhou
1Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine. zjchen21@yahoo.com.cn
Objective:
To research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice.
Method:
By using flow cytometer with CBA software to detect Th1/Th2 type cytokines.
Result:
GLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those of from Th2 were displayed. However, GLA could produce inhibition on IL-2, IFN-gamma and TNF-alpha and acceleration on IL-4 and IL-5.
Conclusion:
Immunosuppressive effect of GLA is related to the influence the level of Th1/Th2 type cytokines.
