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[Effects of Siwu decoction on bone marrow protein expression of blood deficiency mice induced by cyclophosphamide]
Li-Li Liu1, Zeng-Chun Ma, Yu-Guang Wang
1Institute of Radiation Medicine, Beijing 100850, China.
Objective:
To study the effects of Siwu decoction on protein expression of blood deficiency mice induced by cyclophosphamide (CIX) and discuss the possible molecular mechanism on blood enriching function of Siwu decoction.
Method:
Blood deficiency mice were established by injecting ip with 250 mg x kg(-1) CTX. Proteomic technologies were applied to identify the different protein.
Result:
Siwu decoction could restore the changes of 12 up-regulated and 3 down-regulated proteins in bone marrow of blood deficiency mice induced by cyclosphosphamide.
Conclusion:
Siwu decoction could effect expression of proteins which functions including apoptosis, proliferation and differentiation of the haematopoietic stem/progenitor cell. The regulation in the molecular level might be the mechanism of stimulating hematopoiesis in bone marrow fo siwu decocetion.