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Updated: Jul 19, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Efficient microwave-assisted synthesis of amine-substituted tetrakis(pentafluorophenyl)porphyrin
Diana Samaroo1, Clifford E Soll, Louis J Todaro
1Department of Chemistry & Biochemistry, Hunter College and the Graduate Center of the City University of New York, 695 Park Avenue, New York, NY 10021, USA.
Abstract:
We report an efficient and rapid means for the synthesis of tetrakis(pentafluorophenyl)porphyrin (TPPF(20)) derivatives by microwave irradiation in an environmentally acceptable solvent. The selective displacement of the para-fluorine groups in TPPF(20) by primary amines occurs in yields between 70 and 95%. This method demonstrates that TPPF(20) is an ideal platform for the rapid formation of porphyrin conjugates for therapeutic, catalytic, and other applications. [reaction: see text]
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