Related Experiment Video
Updated: Jul 19, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Prevention of breast cancer using selective oestrogen receptor modulators (SERMs)
1Parkside Oncology Centre, Parkside, Wimbledon, London SW19 5NB, UK. hdummer@parkside-hospital.co.uk
Abstract:
Placebo controlled trials in over 25,000 women showed that tamoxifen reduced breast cancer risk by about 40% and osteoporotic fracture risk by about 32%. Similarly placebo controlled trials in nearly 18,000 women showed that raloxifene reduced breast cancer risk by 44-72% and osteoporotic fractures risk by 30-50%. A direct comparison of tamoxifen with raloxifene showed similar risk reduction for breast cancer and osteoporotic fractures with less toxicity for raloxifene.
Related Concept Videos
Cancer Prevention
Some...
Cancer Prevention
Some...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Mitogens and the Cell Cycle
