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Related Experiment Videos

Deep inspiration-induced changes in lung volume decrease with severity of asthma.

Nicola Scichilone1, Roberto Marchese, Simona Soresi

  • 1Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell'Apparato Respiratorio, Università di Palermo, 90146 Palermo, Italy. n.scichilone@libero.it

Respiratory Medicine
|October 20, 2006
PubMed
Summary

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Deep inspiration (DI) causes bronchodilation, but this effect diminishes as asthma severity increases. Reduced DI bronchodilation correlates with worse asthma symptoms and higher medication use, impacting clinical severity.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Deep inspiration (DI) causes bronchodilation, with only slight reduction in mild asthma.
  • The impact of asthma severity on DI-induced bronchodilation requires further investigation.

Purpose of the Study:

  • To assess if increasing asthma severity impairs the bronchodilatory effect of DI.
  • To correlate DI-induced bronchodilation with asthma symptom severity and medication use.

Main Methods:

  • Thirty-six asthmatics were grouped by severity (Intermittent, Mild Persistent, Moderate-Severe) based on GINA guidelines.
  • Methacholine challenge was used to induce bronchoconstriction, followed by 4 deep inspirations (DI) to measure bronchodilation.
  • Bronchodilatory effect was quantified by changes in inspiratory vital capacity (IVC).

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Main Results:

  • The bronchodilatory effect of DI significantly decreased with increasing asthma severity (Intermittent: 68%, Mild Persistent: 45%, Moderate-Severe: 4%).
  • DI-induced bronchodilation showed an inverse correlation with symptom scores and weekly salbutamol usage.
  • FEV(1) and FEV(1)/FVC did not correlate with DI-induced bronchodilation.

Conclusions:

  • The attenuation of DI-induced bronchodilation is associated with increased asthma severity.
  • Impaired DI bronchodilation may contribute to the clinical severity of asthma.
  • DI's bronchodilatory capacity is a potential marker for asthma severity and symptom burden.