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Updated: Jul 19, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
Published on: December 19, 2018
Estrogen receptor beta ligands: design and synthesis of new 2-phenyl-isoindole-1,3-diones
John W Ullrich1, Rayomand J Unwalla, Robert R Singhaus
1Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. ullricj@wyeth.com
Abstract:
The design, synthesis, and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity.
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