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Related Experiment Videos

Intracortical remodeling during human bone development--a histomorphometric study.

Frank Rauch1, Rose Travers, Francis H Glorieux

  • 1Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Québec, Canada H3G 1A6. frauch@shriners.mcgill.ca

Bone
|October 20, 2006
PubMed
Summary
This summary is machine-generated.

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Intracortical bone remodeling slows with age during human development. Bone formation activity is higher in the internal cortex and favors the periosteal side, showing age-dependent and location-specific variations.

Area of Science:

  • Bone Biology
  • Developmental Biology
  • Skeletal Physiology

Background:

  • Intracortical bone remodeling is crucial for bone health.
  • Little is known about this process during human skeletal development.

Purpose of the Study:

  • To investigate intracortical bone remodeling during human development.
  • To analyze age- and location-dependent changes in bone remodeling.

Main Methods:

  • Examined transiliac bone samples from 56 individuals (1.5–22.9 years).
  • Assessed osteonal structure and dynamic measures of intracortical remodeling.
  • Differentiated between external and internal cortex remodeling.

Main Results:

  • Osteonal structure measures were age-independent.

Related Experiment Videos

  • Metabolic activity in osteons decreased with age, indicating slower cortical bone turnover.
  • Internal cortex showed higher bone metabolism than the external cortex.
  • Cortical porosity decreased with age in the external cortex.
  • Bone formation activity favored the periosteal side of osteonal canals.

    • Conclusions:

    • Intracortical remodeling activity changes significantly during human bone development.
    • Remodeling processes are age-dependent and exhibit spatial variation within the same bone.
    • Developmental bone remodeling is asymmetric between the internal and external cortices.