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Published on: October 11, 2018
Functional variations in the JWA gene are associated with increased odds of leukemias
Qun Shen1, Wei-Yan Tang, Chun-Ping Li
1Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University,140 Hanzhong Road, Nanjing 210029, People's Republic of China.
Abstract:
The association between the -76G>C in the 5'-flanking region and 723T>G in JWA exon three variants were examined for risk of leukemia development in a hospital-based case-control study of 201 leukemia patients and 243 cancer-free controls in a Chinese population. Studies showed that the -76C allele was associated with significantly increased odds of leukemia but the 723G allele was correlated with marked decreased odds of leukemia. Variation in the -76C allele resulted in almost complete loss of oxidative stress stimulated transcription activities of the promoter fragment.
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