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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
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Novel polymeric microspheres containing norcantharidin for chemoembolization.

Xiaohua Liu1, Wan Sia Heng, Paul

  • 1Department of Pharmacy, National University of Singapore, Singapore.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|October 20, 2006
PubMed
Summary

Poly(lactic-co-glycolic acid) (PLGA)-alginate microspheres loaded with norcantharidin show promise for chemoembolization. These composite microspheres effectively inhibit cancer cell growth and demonstrate therapeutic effects in animal models.

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Last Updated: Jul 19, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

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Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

Area of Science:

  • Biomaterials Science
  • Oncology
  • Drug Delivery Systems

Background:

  • Chemoembolization is a cancer treatment combining embolization with chemotherapy.
  • Developing effective drug delivery systems is crucial for targeted cancer therapy.

Purpose of the Study:

  • To evaluate PLGA-alginate microspheres for chemoembolization.
  • To investigate the anti-tumor efficacy of norcantharidin-loaded microspheres.

Main Methods:

  • Fabrication and characterization of alginate, PLGA, and PLGA-alginate microspheres.
  • In vitro drug release studies in phosphate-buffered saline.
  • In vitro cytotoxicity assays on cancer cells.
  • In vivo evaluation in a rat tumor model.

Main Results:

  • PLGA-alginate microspheres exhibited optimal drug release kinetics for chemoembolization.
  • Increased alginate content reduced burst release and increased particle size.
  • Norcantharidin-loaded microspheres demonstrated concentration- and time-dependent cancer cell growth inhibition.
  • Microspheres showed significant embolization and therapeutic effects in vivo.

Conclusions:

  • PLGA-alginate composite microspheres are a suitable platform for chemoembolization.
  • Norcantharidin-loaded microspheres offer a promising strategy for targeted cancer therapy.
  • The developed microspheres present excellent embolization and therapeutic potential.