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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
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Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

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Updated: Jul 19, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
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Incomplete immunisation uptake in infancy: maternal reasons.

Lamiya Samad1, Neville Butler, Catherine Peckham

  • 1Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK.

Vaccine
|October 20, 2006
PubMed
Summary

Most UK infants receive primary immunisations, but some mothers cite medical or belief-based reasons for incomplete vaccination. Understanding these maternal reasons is key to improving infant immunization rates.

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Area of Science:

  • Pediatrics
  • Public Health
  • Sociology

Background:

  • Infant immunization is crucial for preventing childhood diseases.
  • Understanding parental vaccine hesitancy is vital for public health initiatives.
  • The Millennium Cohort Study provides valuable data on child development and health in the UK.

Purpose of the Study:

  • To investigate the uptake of primary infant immunizations in the UK.
  • To identify and analyze the reasons mothers provide for incomplete or absent infant immunization.
  • To inform strategies for enhancing childhood vaccination coverage.

Main Methods:

  • Analysis of data from the Millennium Cohort Study, a large UK-based cohort.
  • Inclusion of 18,819 infants born between September 2000 and January 2002.
  • Categorization of immunization status (fully, partially, unimmunized) and associated maternal reasons.

Main Results:

  • 95.6% of infants were fully immunized, 3.3% partially, and 1.1% unimmunized.
  • Medical reasons were most common for partial immunization (45%).
  • Beliefs or attitudes were the primary reasons for non-immunization (47%).

Conclusions:

  • While infant immunization rates are high, a significant minority remain unvaccinated or undervaccinated.
  • Maternal reasons for incomplete immunization vary, with medical concerns and personal beliefs being prominent.
  • Targeted interventions addressing specific maternal concerns are needed to maximize infant immunization uptake.