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Related Experiment Videos

Multifocal visual evoked potentials in the anesthetized non-human primate.

Nathan A Maertz1, Charlene B Y Kim, T Michael Nork

  • 1Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792-3220, USA.

Current Eye Research
|October 20, 2006
PubMed
Summary

Monkey multifocal visual evoked cortical potentials (mfVEPs) are reliable and distinct from electroretinographic (ERG) activity. This method shows promise for studying visual field responses in animal models.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Animal Models

Background:

  • Multifocal visual evoked cortical potentials (mfVEPs) assess central and peripheral visual function.
  • Reliable mfVEP recording in non-human primates is crucial for translational research.

Purpose of the Study:

  • To evaluate the reliability and isolation of monkey mfVEPs from electroretinographic (ERG) activity.
  • To assess mfVEPs recorded from central and peripheral visual fields.

Main Methods:

  • mfVEPs were recorded from normal and surgically altered monkeys (optic nerve transection/ocular hypertension) under pentobarbital anesthesia.
  • A 7-element hexagonal array stimulus subtended 80 degrees of the central visual field.
  • Longitudinal testing and comparison with normal animals were performed.

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Main Results:

  • Robust mfVEPs (K1 and K2.1) were recorded from non-transected eyes.
  • No mfVEP contamination from concurrent multifocal ERGs was observed in transected eyes.
  • mfVEP amplitudes were distinct from noise and showed separation between transected and fellow eyes over time.

Conclusions:

  • Pentobarbital anesthesia allows reliable mfVEP recording in non-human primates.
  • The described recording conditions ensure mfVEPs are free from ERG contamination.
  • mfVEPs are valuable for animal models investigating diseases affecting specific visual field regions.