Related Experiment Video
Updated: Jul 19, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Which factors are important predictors of non-recovery from major depression? A 2-year prospective observational
Heimo Viinamäki1, Kaisa Haatainen, Kirsi Honkalampi
1Department of Psychiatry, Kuopio University Hospital, University of Kuopio, Finland. heimo.viinamaki@kuh.fi
Abstract:
Our aim was to study factors associated with long-term non-recovery from major depression. A total of 109 patients with major depression were followed prospectively for 2 years. A diagnosis of major depression based on SCID interviews at follow-up indicated non-recovery. The effect of several established risk factors was assessed. A third (30%) of the patients did not recover. Severity of initial depression were associated with poor outcome according to univariate analysis. Nevertheless, personality disorder and rural area of residence were associated with non-recovery in final multivariate analysis. Major depression in patients with personality disorder should be treated as effectively as possible. Moreover, service planning in rural areas needs attention.
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression
Psychological and Sociocultural Causes of Schizophrenia
Depressive Disorders: MDD and Dysthymia
Depression: Overview