Related Experiment Video
Updated: Jul 19, 2026
09:52
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
The debate: a case for randomized controls in invasive aspergillosis
1Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. jbennett@niaid.nih.gov
Medical Mycology
|October 20, 2006
Summary
Randomized trials show liposomal amphotericin B may be superior and less toxic than conventional amphotericin B for invasive aspergillosis. Voriconazole also demonstrates superior outcomes compared to conventional amphotericin B.
Area of Science:
- Mycology
- Infectious Diseases
- Clinical Trials
Background:
- Invasive aspergillosis diagnosis and treatment have evolved.
- Standardized definitions and diagnostic criteria (e.g., HRCT, BAL) improve trial interpretation.
- Global collaboration has enhanced clinical trial enrollment and statistical power.
Purpose of the Study:
- To review and synthesize findings from randomized trials in invasive aspergillosis.
- To compare the efficacy and toxicity of different antifungal agents.
- To guide optimal antifungal drug selection in clinical practice.
Main Methods:
- Analysis of aggregated data from randomized controlled trials.
- Comparison of outcomes including efficacy, toxicity, and specific adverse events.
- Evaluation of different dosing strategies and drug formulations.
Main Results:
- Liposomal amphotericin B demonstrates potential superiority and reduced toxicity versus conventional amphotericin B at 14 days.
- Amphotericin B colloidal dispersion shows less nephrotoxicity but more infusion reactions than conventional amphotericin B.
- Voriconazole initiation is superior to conventional amphotericin B for invasive aspergillosis treatment.
Conclusions:
- Randomized trials provide crucial evidence for antifungal drug selection.
- Voriconazole and liposomal amphotericin B represent significant advancements in invasive aspergillosis therapy.
- Evidence supports informed, cost-effective antifungal drug use in clinical settings.
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