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The correlation between asthma control and health status: the GOAL study
E D Bateman1, J Bousquet, M L Keech
1University of Cape Town, Cape Town, South Africa. ebateman@uctgsh1.uct.ac.za
The European Respiratory Journal
|October 20, 2006
Summary
Achieving higher asthma control levels, like total control (TC) and well-controlled (WC) asthma, significantly improves health-related quality of life (HRQoL). This study shows HRQoL nears normal as asthma control intensifies.
Area of Science:
- Pulmonology
- Clinical Trials
- Quality of Life Research
Background:
- Asthma control is crucial for patient well-being.
- Guideline-derived measures define asthma control levels.
- Health-related quality of life (HRQoL) is a key outcome in asthma management.
Purpose of the Study:
- To assess the association between guideline-derived asthma control and HRQoL.
- To compare fluticasone propionate (FP) and salmeterol/fluticasone propionate (SFC) in achieving asthma control.
- To evaluate HRQoL using the Asthma Quality of Life Questionnaire (AQLQ).
Main Methods:
- Randomized, double-blind, parallel-group study design.
- Dose augmentation of FP or SFC until total control (TC), well-controlled (WC), or maximum dose.
- AQLQ assessments at baseline and regular clinic visits over 52 weeks.
Main Results:
- AQLQ scores improved significantly across all control groups (TC, WC, not well-controlled [NWC]).
- Near-maximal AQLQ levels were achieved in patients reaching TC and WC.
- Statistically significant differences in 52-week mean AQLQ scores were observed between control groups.
Conclusions:
- Treatments aimed at intensifying asthma control improve HRQoL towards normal levels.
- Clinically meaningful improvements in AQLQ scores were noted with increasing asthma control.
- Patients can differentiate HRQoL benefits even between high levels of asthma control (TC vs. WC).
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