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Interdigitating reticulum cells in human renal grafts.
1Central Clinic Laboratory, University of Tokyo, Japan.
Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1991
Summary
Interdigitating reticulum cells (IDC) or dendritic cells (DC) are not typically found in healthy human kidney tissue. Their presence in renal grafts suggests they originate from the recipient
Area of Science:
- Nephrology
- Immunology
- Transplantation Biology
Background:
- Interdigitating reticulum cells (IDC) and dendritic cells (DC) are crucial immune cells involved in antigen presentation.
- Their presence and origin in human renal allografts remain incompletely understood.
Purpose of the Study:
- To investigate the presence and localization of IDC/DC in human renal graft biopsies.
- To determine the origin (recipient vs. donor) of IDC/DC in renal allografts.
Main Methods:
- Immunoelectron microscopy was employed on 17 human renal graft biopsies and 3 non-graft renal biopsies.
- Specific antibodies targeting S100 beta protein, HLA-DR, CD3, and CD1a were used for cell identification.
- Biopsies were collected from 1 hour to 50 days post-transplantation.
Main Results:
- IDC/DC were identified in 11 out of 17 renal grafts, but not in any of the non-graft renal tissues.
- These cells were found in glomerular and interstitial capillary lumens and interstitium, with varying patterns.
- In grafts with early (1-hour) and later detection, IDC/DC presence suggests a recipient origin and migration from circulating blood.
Conclusions:
- IDC/DC are likely not normal residents of human renal tissue.
- The presence of IDC/DC in renal grafts suggests they are derived from the recipient's circulating immune cells.
- These cells appear to migrate into the graft interstitium and vasculature post-transplantation.