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Primary cutaneous multifocal CD30+ anaplastic large cell lymphoma.
L K Asha1, Daisy Thomas, M P Binitha
1Department of Dermatology and Venereology, Medical College, Calicut, Kerala, India.
Indian Journal of Dermatology, Venereology and Leprology
|October 20, 2006
Summary
A 45-year-old male was diagnosed with CD30+ anaplastic primary cutaneous large cell lymphoma presenting as widespread asymptomatic tumors and enlarged lymph nodes. Despite a dramatic response to chemotherapy, the condition recurred, highlighting treatment challenges.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Anaplastic primary cutaneous large cell lymphoma (APCLC) is a rare non-Hodgkin lymphoma.
- It typically presents as reddish-brown nodules, often with ulceration.
- Lymph node involvement is infrequent, occurring in approximately 25% of cases.
Observation:
- A 45-year-old male presented with asymptomatic, non-ulcerated tumors across his body.
- Generalized, firm, enlarged, and nontender lymph nodes were noted.
- No hepatosplenomegaly was present.
Findings:
- Biopsy and immunophenotyping confirmed CD30+ anaplastic primary cutaneous large cell lymphoma.
- The patient's lesions responded well to chemotherapy.
- Recurrence of the lymphoma was observed post-treatment.
Implications:
- This case underscores the variable presentation of APCLC, including asymptomatic, non-ulcerated tumors and significant lymph node involvement.
- The dramatic but temporary response to chemotherapy highlights the need for further research into effective long-term treatment strategies for APCLC.
- Understanding atypical presentations is crucial for timely diagnosis and management of cutaneous lymphomas.
