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Vulvar paget disease: one century after first reported
Mario Preti1, Leonardo Micheletti, Marco Massobrio
11Department of Gynecology and Obstetrics, University of Turin, Turin, Italy; 2Department of Dermatology, Akita University School of Medicine, Akita City, Japan; and 3Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL.
Journal of Lower Genital Tract Disease
|October 20, 2006
Summary
This study reviews vulvar Paget disease literature, proposing a classification into primary and secondary types. This distinction is crucial for guiding individualized patient treatment and improving prognosis.
Area of Science:
- Gynecologic Oncology
- Dermatopathology
Background:
- Vulvar Paget disease (VPD) is a rare intraepithelial adenocarcinoma.
- Accurate diagnosis and classification are essential for effective management.
Purpose of the Study:
- To critically assess the literature on vulvar Paget disease.
- To propose a classification system for individualized patient care.
Main Methods:
- Comprehensive literature search of Medline and Ovid databases up to June 2002.
- Exclusion of case reports, letters, and abstracts to focus on substantial studies.
Main Results:
- VPD can be classified into primary and secondary types, impacting clinical approach and prognosis.
- Primary VPD treatment involves wide surgical excision; lymphadenectomy is indicated for invasive neoplasms.
- Secondary VPD requires treatment of the associated underlying carcinoma.
Conclusions:
- Subclassification of VPD into primary and secondary is vital for optimal clinical management.
- Immunohistochemistry can aid in differentiating between primary and secondary vulvar Paget disease.
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