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Updated: Jul 17, 2026

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Lymphoepithelioma-like carcinoma of the vulva
Weiwei Niu1, Debra S Heller, Cyril D'Cruz
1Departments of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, Newark, NJ, USA
Abstract:
Lymphoepithelioma is well known in the nasopharyngeal region. Although this neoplasm is well described in a variety of extranasal sites, where it is termed lymphoepithelioma-like carcinoma, this is only the second report of this neoplasm originating in the vulva reported in the literature. These lesions are reported to be less aggressive in extranasal sites. A 40-year-old woman presented with a lymphoepithelioma-like carcinoma of the vulva, diagnosed by excisional biopsy, which had been present for 1 month. The lesion persisted with ipsilateral lymph node involvement 4 months after initial resection, when the patient returned for definitive surgery. Lymphoepithelioma-like carcinoma can occur rarely in the vulva, and may behave aggressively.
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