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Updated: Jul 19, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 8, 2024
[Complex Regional Pain (CRPS) Syndrome type II. Timing for surgery and therapeutic options: neuromodulation]
G Monacelli1, L Valesini, M I Rizzo
1Neuromed, IRCCS, Pozzilli, Isernia, Italia. giampaolo.monacelli@uniroma1.it
Objective:
The object of this study is to evaluate the importance of a correct timing for surgery, the different strategies of therapy and the use of the neuromodulation in the Complex Regional Pain Syndrome (CRPS) type II.
Patients And Methods:
The last 2 years we observed 8 patients with the clinical picture of a CPRS type II, due to previous peripheral nerve lesions of the upper extremity. All the patients followed a therapeutic protocol of neuromodulation and reconstructive surgical repair.
Results:
Six patients out of eight had almost a complete recovery of the symptoms 6 months after the surgery.
Conclusions:
Our study demonstrates that the patients who underwent surgical repair followed by neuromodulation didn't present any recurrence of the symptoms.

