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Updated: Jul 19, 2026

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
[Relationship between seizure duration and bispectral index during modified electroconvulsive therapy]
Shinichiro Miyazaki1, Tadatoshi Muratani, Kenji Morimoto
1Department of Anesthesiology, Osaka Medical College, Takatsuki 569-8686.
The bispectral index (BIS) can predict effective seizure duration during anesthesia for modified electroconvulsive therapy (mECT). A BIS range of 53.6-58.8 indicates optimal seizure length.
Area of Science:
- Anesthesiology
- Neuroscience
- Critical Care Medicine
Context:
- Modified electroconvulsive therapy (mECT) is a treatment for severe psychiatric disorders.
- The relationship between seizure duration and bispectral index (BIS) during mECT is not well understood.
- Anesthesia, typically with propofol and suxamethonium, is used during mECT.
Purpose:
- To investigate the correlation between BIS values and seizure duration in mECT.
- To determine if BIS can be used to optimize seizure duration during mECT.
Summary:
- This study examined BIS changes and seizure duration during mECT under propofol and suxamethonium anesthesia.
- A significant correlation was found between the BIS value before electrical stimulation and seizure duration.
- An effective seizure duration was observed within a BIS range of 53.6-58.8.
Impact:
- Findings suggest that BIS monitoring can help determine the optimal timing for electrical stimulation in mECT.
- This could lead to more consistent and effective seizure induction during mECT.
- Potential for improved patient outcomes and treatment efficacy in mECT.
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