Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ran at kinetochores.

M Dasso1

  • 1Laboratory of Gene Regulation and Development, NICHD (National Institute of Child Health and Human Development)/NIH (National Institutes of Health), Bethesda, MD 20892-5431, USA. mdasso@helix.nih.gov

Biochemical Society Transactions
|October 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.

Nature communications·2021
Same author

[Assembly of correct kinetochore architecture in Xenopus laevis egg extract requires transition of sperm DNA through interphase].

Tsitologiia·2007
Same author

The promyelocytic leukemia protein stimulates SUMO conjugation in yeast.

Oncogene·2006
Same author

Partial characterization of a human submandibular/sublingual salivary adhesion-promoting protein.

Archives of oral biology·2002
Same author

Expression and regulation of the mammalian SUMO-1 E1 enzyme.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2001
Same author

Bitter taste transduced by PLC-beta(2)-dependent rise in IP(3) and alpha-gustducin-dependent fall in cyclic nucleotides.

American journal of physiology. Cell physiology·2001
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
See all related articles

The Ran GTPase protein is crucial for cell division, particularly in organizing mitotic spindles and regulating the spindle assembly checkpoint at kinetochores. Further research is needed to fully understand these kinetochore-associated functions.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The Ran GTPase regulates key cellular processes like nucleocytoplasmic transport and cell cycle progression.
  • Ran-GTP gradients near mitotic chromatin are known to aid in mitotic spindle organization.
  • Less is understood about Ran's specific roles at mitotic kinetochores.

Purpose of the Study:

  • To summarize the evidence for Ran GTPase's kinetochore-associated functions.
  • To highlight the importance of Ran in spindle assembly checkpoint regulation and kinetochore-microtubule attachment.
  • To identify outstanding questions regarding Ran's kinetochore roles.

Main Methods:

  • Literature review and synthesis of existing research on Ran GTPase.
  • Focus on studies investigating kinetochore-associated functions of Ran.

Related Experiment Videos

  • Identification of key experimental findings and unresolved issues.

    • Main Results:

    • Ran GTPase plays a critical role at mitotic kinetochores.
    • It is essential for the spindle assembly checkpoint (SAC).
    • It is also vital for the assembly of microtubules connecting kinetochores to spindle poles.

    Conclusions:

    • Ran GTPase has significant, yet underappreciated, roles at mitotic kinetochores.
    • These roles include SAC regulation and microtubule fiber assembly.
    • Further investigation is required to fully elucidate these kinetochore-specific functions.