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Updated: Jul 19, 2026

Microfluidic Mixers for Studying Protein Folding
Published on: April 10, 2012
Folding and unfolding for binding: large-scale protein dynamics in protein-protein interactions
1Henry Wellcome Laboratories for Structural Biology, Department of Biochemistry, Henry Wellcome Building, University of Leicester, P.O. Box 138, Lancaster Road, Leicester LE1 9HN, UK. gcr@le.ac.uk
Abstract:
The role of dynamics in the function of proteins, from enzymes to signalling proteins, is widely recognized. In many cases, the dynamic process is a relatively localized one, involving motion of a limited number of key residues, while in others large-scale domain movements may be involved. These motions all take place within the context of a folded protein; however, there is increasing evidence for the existence of some proteins where a transition between folded and unfolded structures is required for function.
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