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Related Experiment Video

Updated: Jul 16, 2026

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Published on: August 26, 2011

Common Kibra alleles are associated with human memory performance.

Andreas Papassotiropoulos¹, Dietrich A Stephan, Matthew J Huentelman

¹Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland. papas@bli.unizh.ch

Science (New York, N.Y.)

|October 21, 2006

Summary

Researchers identified the KIBRA gene variant associated with human memory performance. This brain protein plays a role in memory retrieval, as shown by functional magnetic resonance imaging studies in cognitively normal individuals.

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Area of Science:

Neuroscience
Genetics
Cognitive Psychology

Background:

Human memory is influenced by multiple genes, making it a complex polygenic trait.
Identifying specific genetic factors contributing to memory function is crucial for understanding cognitive abilities.

Purpose of the Study:

To conduct a genome-wide screen to identify gene variants associated with human memory performance.
To investigate the role of the KIBRA gene in memory function.

Main Methods:

Genome-wide association study (GWAS) in three independent cohorts of cognitively normal individuals.
Gene expression analysis in brain tissues.
Functional magnetic resonance imaging (fMRI) during memory retrieval tasks.

Main Results:

A specific genomic locus encoding the KIBRA gene was significantly associated with memory performance across all cohorts.
KIBRA gene expression was detected in brain regions critical for memory.
fMRI revealed KIBRA allele-dependent differences in hippocampal activation during memory recall.

Conclusions:

The KIBRA gene is implicated in human memory performance.
KIBRA likely influences memory through its role in hippocampal function during memory retrieval.