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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Related Experiment Video

Updated: Jul 19, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Published on: December 15, 2011

Systemic autoimmune disorders in celiac disease.

Alessio Fasano1

  • 1Center for Celiac Research and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. afasano@mbrc.umaryland.edu

Current Opinion in Gastroenterology
|October 21, 2006
PubMed
Summary

Celiac disease (CD) is linked to other autoimmune disorders. While the exact cause is unclear, impaired intestinal barrier function in CD may trigger other autoimmune conditions, suggesting early diagnosis and treatment could halt progression.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Genetics

Background:

  • Celiac disease (CD) is an immune-mediated disorder with diverse clinical manifestations.
  • A significant comorbidity exists between CD and other autoimmune diseases.
  • Understanding this association is crucial for patient management and disease prevention.

Purpose of the Study:

  • To review the current literature on the comorbidity between celiac disease and other autoimmune disorders.
  • To evaluate the two main theories explaining this association: genetic linkage and the impact of untreated CD.
  • To contextualize findings within recent advances in CD pathogenesis.

Main Methods:

  • Literature review of studies investigating the comorbidity of celiac disease and autoimmune disorders.
  • Analysis of genetic data concerning linkage disequilibrium.
  • Examination of evidence linking intestinal barrier dysfunction to autoimmune disease onset.

Main Results:

  • Two primary theories exist: genetic linkage and untreated CD leading to other autoimmune diseases.
  • Current literature does not definitively favor one theory over the other.
  • Emerging evidence suggests that loss of intestinal barrier function in CD may be a key factor.

Conclusions:

  • The precise mechanisms underlying CD comorbidity with other autoimmune diseases remain incompletely understood.
  • Impaired intestinal barrier function in CD is increasingly implicated as a potential trigger for other autoimmune conditions.
  • Prompt diagnosis and treatment of CD may prevent or reverse autoimmune responses by addressing the loss of barrier function.