Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

7.0K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
7.0K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.9K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.9K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.4K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.4K
Embryonic Stem Cells00:58

Embryonic Stem Cells

29.3K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
29.3K
Stem Cell Culture01:17

Stem Cell Culture

5.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.6K
Stem Cell Niche01:26

Stem Cell Niche

5.4K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth.

ACS chemical biology·2024
Same author

Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells.

iScience·2024
Same author

Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis.

Cancer research·2024
Same author

After DNA damage, AREG-ular niche it's not.

Blood·2023
Same author

IMAGE-seq and you shall find.

Nature methods·2023
Same author

Tet2 helps blood cells balance in air.

Blood·2022
Same journal

Dynamic myeloid suppressor states in cancer and inflammation and their therapeutic potential.

Current opinion in hematology·2026
Same journal

Factor XIa inhibition for the prevention of thrombosis: mechanism, clinical trial signals, and indication-specific positioning.

Current opinion in hematology·2026
Same journal

Nutrition as a regulator of hematopoietic stem cell biology and transplantation.

Current opinion in hematology·2026
Same journal

From biomimicry to clinical actionability: rethinking high-shear thrombosis as a mechanobiological system.

Current opinion in hematology·2026
Same journal

Bidirectional relationship between metabolic and thrombotic disease mechanisms.

Current opinion in hematology·2026
Same journal

The dual role of the brain-derived neurotrophic factor as a regulator of hemostasis and thrombotic risk.

Current opinion in hematology·2026
See all related articles

Related Experiment Video

Updated: Oct 15, 2025

Efficient Retroviral Transduction and Competitive Homing for Investigating GPCR-Mediated T-Cell Localization in Diverse Tissue Microenvironments
09:12

Efficient Retroviral Transduction and Competitive Homing for Investigating GPCR-Mediated T-Cell Localization in Diverse Tissue Microenvironments

Published on: March 28, 2025

359

Stem cell homing.

John P Chute1

  • 1Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina 27710, USA. john.chute@duke.edu

Current Opinion in Hematology
|October 21, 2006
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cell homing to bone marrow involves complex molecular interactions and specialized niches. Understanding these processes is key for successful stem cell transplantation and therapies.

More Related Videos

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
11:37

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

6.7K
Homing of Hematopoietic Cells to the Bone Marrow
10:40

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 17, 2009

29.7K

Related Experiment Videos

Last Updated: Oct 15, 2025

Efficient Retroviral Transduction and Competitive Homing for Investigating GPCR-Mediated T-Cell Localization in Diverse Tissue Microenvironments
09:12

Efficient Retroviral Transduction and Competitive Homing for Investigating GPCR-Mediated T-Cell Localization in Diverse Tissue Microenvironments

Published on: March 28, 2025

359
Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
11:37

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

6.7K
Homing of Hematopoietic Cells to the Bone Marrow
10:40

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 17, 2009

29.7K

Area of Science:

  • Hematology
  • Cell Biology
  • Immunology

Background:

  • Hematopoietic stem cell (HSC) transplantation relies on successful homing, engraftment, and repopulation within the bone marrow.
  • Stem cell homing to the bone marrow is a critical initial step for engraftment and therapeutic success.

Purpose of the Study:

  • To review recent advancements in understanding the molecular mechanisms of stem cell homing.
  • To explore the specialized bone marrow niches that support stem cell residence.

Main Methods:

  • Literature review of recent studies on stem cell homing.
  • Analysis of molecular and cellular processes involved in stem cell migration.

Main Results:

  • Significant progress in defining the molecular basis of HSC adhesion, rolling, and transmigration along bone marrow endothelium.
  • Identification of mechanisms governing HSC enlodgement within bone marrow niches.
  • Demonstration that HSC homing pathways also influence extramedullary migration and cancer stem cell metastasis.

Conclusions:

  • Key components regulating stem cell homing include cell adhesion molecules, extracellular matrix, chemokines, and bone marrow niche microenvironments.
  • Enhanced understanding of stem cell homing has spurred the development of novel mobilization therapies.