Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

T-FINDER: A highly sensitive, pan-HLA platform for functional T cell receptor and ligand discovery.

Science advances·2024
Same author

CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses.

Science (New York, N.Y.)·2023
Same author

Publisher Correction: A RORγt<sup>+</sup> cell instructs gut microbiota-specific T<sub>reg</sub> cell differentiation.

Nature·2022
Same author

A RORγt<sup>+</sup> cell instructs gut microbiota-specific T<sub>reg</sub> cell differentiation.

Nature·2022
Same author

Phase-variable bacteria simultaneously express multiple capsules.

Microbiology (Reading, England)·2021
Same author

The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.

Science immunology·2021

Related Experiment Video

Updated: Jul 19, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

Learning from the lost: new insights into TCR specificity

Nathan J Felix, Paul M Allen

    Nature Immunology
    |October 21, 2006
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
    09:53

    Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

    Published on: February 6, 2017

    Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
    08:48

    Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

    Published on: October 25, 2016

    Related Experiment Videos

    Last Updated: Jul 19, 2026

    Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
    19:05

    Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

    Published on: October 30, 2015

    Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
    09:53

    Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

    Published on: February 6, 2017

    Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
    08:48

    Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

    Published on: October 25, 2016