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Updated: Jul 19, 2026

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
Published on: January 1, 2018
STDP rule endowed with the BCM sliding threshold accounts for hippocampal heterosynaptic plasticity
Lubica Benuskova1, Wickliffe C Abraham
1Knowledge Engineering & Discovery Research Institute, Auckland University of Technology, Auckland, New Zealand. lbenusko@aut.ac.nz
Abstract:
We have combined the nearest neighbour additive spike-timing-dependent plasticity (STDP) rule with the Bienenstock, Cooper and Munro (BCM) sliding modification threshold in a computational model of heterosynaptic plasticity in the hippocampal dentate gyrus. As a result we can reproduce (1) homosynaptic long-term potentiation of the tetanized input, and (2) heterosynaptic long-term depression of the untetanized input, as observed in real experiments.
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