Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opioid antagonists for smoking cessation.

S David1, T Lancaster, L F Stead

  • 1Brown University School of Medicine, Department of Family Medicine, Memorial Hospital of Rhode Island, Providence, Rhode Island, USA. sean_david@brown.edu

The Cochrane Database of Systematic Reviews
|October 21, 2006
PubMed
Summary

Opioid antagonists like naltrexone show no significant effect in helping smokers quit long-term. More research is needed to determine naltrexone

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence of radiation necrosis following different radiotherapy fractionation schedules for intracranial meningiomas.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2025
Same author

Most oncological pancreas resections must consider the mesopancreas.

BMC cancer·2025
Same author

Editorial: Glioma: from genetic to cellular heterogeneity.

Frontiers in cell and developmental biology·2024
Same author

Outer membrane vesicles as nanovaccine candidates against pathogenic Leptospira in experimental Guinea pig model.

Biologicals : journal of the International Association of Biological Standardization·2024
Same author

Editorial: Artificial intelligence to enhance biomechanical modelling.

Frontiers in sports and active living·2023
Same author

Testing the Limit Range of Motion Safety Function of Upper Limb Rehabilitation Robots with an Anthropometrically Adjustable and Sensorized Dummy Limb<sup></sup>.

IEEE ... International Conference on Rehabilitation Robotics : [proceedings]·2022

Area of Science:

  • Addiction research
  • Pharmacology
  • Clinical trials

Background:

  • Nicotine's reinforcing effects are mediated by neurotransmitter release.
  • Smokers report pleasure, relaxation, and relief from negative affect.
  • Opioid antagonists are investigated for attenuating smoking's rewarding effects.

Purpose of the Study:

  • To evaluate opioid antagonists' efficacy in long-term smoking cessation.
  • Specific drugs examined include naloxone and naltrexone.

Main Methods:

  • Searched specialized registers and MEDLINE for relevant trials.
  • Included randomized controlled trials with at least six months of follow-up data.
  • Performed meta-analysis using a fixed-effect model for abstinence rates.

Related Experiment Videos

Main Results:

  • Four naltrexone trials met criteria; none showed significant quit rate differences versus placebo.
  • Pooled analysis revealed no significant effect of naltrexone on long-term abstinence (OR 1.26, 95% CI 0.80-2.01).
  • No long-term follow-up data were available for naloxone or buprenorphine trials.

Conclusions:

  • Limited data prevent confirming or refuting naltrexone's efficacy for smoking cessation.
  • Confidence intervals are wide, allowing for both benefit and potential negative effects.
  • Larger trials are necessary to definitively assess naltrexone's effectiveness in smoking cessation.