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Related Experiment Videos

Risperidone in long-term treatment for bipolar disorder.

J M Rendell¹, J R Geddes

¹University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, UK. jennifer.rendell@psych.ox.ac.uk

The Cochrane Database of Systematic Reviews

|October 21, 2006

Summary

This review found no randomized trials on long-term risperidone use for bipolar disorder relapse prevention. More research is needed to establish risperidone

Area of Science:

Psychiatry
Pharmacology
Clinical Trials

Background:

Risperidone, an atypical antipsychotic, is used for acute manic episodes, often continuing for long-term relapse prevention in bipolar disorder.
Evidence for the long-term effectiveness and safety of risperidone in bipolar disorder is needed.

Purpose of the Study:

To evaluate randomized evidence on risperidone's efficacy and tolerability for long-term bipolar disorder relapse prevention.
To compare risperidone against placebo or other pharmacological treatments.

Main Methods:

Searched multiple databases (CCDANCTR-Studies, CENTRAL, EMBASE, MEDLINE, CINAHL, PsycINFO) in October 2005.
Included randomized trials comparing risperidone with placebo or other drugs for long-term relapse prevention in bipolar disorder.

Related Experiment Videos

Searched reference lists, textbooks, and contacted researchers.

Main Results:

No randomized trials were identified that compared risperidone with other treatments for preventing manic or depressive relapses in bipolar disorder.

Conclusions:

There is a significant need for randomized controlled trials (RCTs) to assess risperidone for bipolar disorder relapse prevention.
Future RCTs should focus on randomized treatment for relapse prevention with long-term follow-up.