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Related Experiment Videos

Systemic antimicrobial prophylaxis for percutaneous endoscopic gastrostomy.

A Lipp¹, G Lusardi

¹University of Glamorgan, School of Care Sciences, Glyntaff, Pontypridd, UK. alipp@glam.ac.uk

The Cochrane Database of Systematic Reviews

|October 21, 2006

Summary

Prophylactic antibiotics significantly reduce peristomal infections in patients undergoing percutaneous endoscopic gastrostomy (PEG) placement. This finding supports the use of antibiotics to prevent infections associated with PEG procedures.

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Area of Science:

Gastroenterology
Infectious Diseases
Surgical Prophylaxis

Background:

Percutaneous endoscopic gastrostomy (PEG) is crucial for nutritional support but carries infection risks, especially in vulnerable patients.
The rising incidence of methicillin-resistant Staphylococcus aureus (MRSA) heightens concerns regarding infections and antibiotic prophylaxis for PEG procedures.
Surgical antimicrobial prophylaxis aims to achieve bactericidal drug concentrations at the time of PEG placement to prevent infections.

Purpose of the Study:

To determine if prophylactic systemic antimicrobials decrease peristomal infection risk in patients undergoing PEG placement.
To evaluate the efficacy of antibiotic prophylaxis in reducing complications associated with PEG procedures.

Main Methods:

A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted.
Searches included major databases (Cochrane, PubMed) and handsearches of relevant literature.
Data extraction and quality assessment were performed by two authors, with meta-analysis for pooled results.

Main Results:

Ten RCTs involving 1100 patients were analyzed.
Prophylactic antibiotics demonstrated a statistically significant reduction in peristomal infection incidence (pooled OR 0.31, 95% CI 0.22 to 0.44).
All included trials reported peristomal infection as a key outcome measure.

Conclusions:

Systemic prophylactic antibiotics are effective in reducing peristomal infections following PEG placement.
The findings support the routine use of antibiotic prophylaxis to improve outcomes for PEG procedures.