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Postchallenge glucose rises with increasing age even when glucose tolerance is normal
1Emory University School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Lipids, Atlanta, GA 30303, USA. mrhee@emory.edu
Aging is linked to higher 1-hour post-oral glucose challenge (1-h OGTT) glucose levels, even with normal glucose tolerance (NGT). This age-related glucose handling impairment may increase cardiovascular disease risk.
Area of Science:
- Endocrinology
- Gerontology
- Metabolic Health
Background:
- Aging is a significant risk factor for type 2 diabetes and cardiovascular disease.
- Elevated glucose levels post-oral glucose challenge are indicative of impaired glucose metabolism.
- Understanding glucose dynamics in aging populations is crucial for early risk assessment.
Purpose of the Study:
- To investigate the association between age and 1-hour post-oral glucose challenge (1-h OGTT) glucose concentrations.
- To determine if this association persists in individuals with normal glucose tolerance (NGT).
Main Methods:
- Cross-sectional study utilizing the NHANES II database.
- Analysis of 2591 subjects with NGT and documented 1-h OGTT.
- Multivariable linear regression to assess the relationship between age and 1-h OGTT glucose.
Main Results:
- Each 10-year increase in age was associated with a 0.20 mmol/l rise in 1-h OGTT glucose (P < 0.0001).
- A significant interaction between age and gender was observed, with faster glucose rise in men.
- The effect of age on 1-h OGTT glucose was independent of fasting and 2-h OGTT glucose levels.
Conclusions:
- 1-h OGTT glucose concentrations increase with age, even in individuals with NGT.
- This age-related impairment in glucose handling warrants further investigation for its pathophysiological significance.
- Such findings may indicate an elevated cardiovascular disease risk in aging individuals, irrespective of diabetes or prediabetes diagnosis.
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