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Related Experiment Videos

Postchallenge glucose rises with increasing age even when glucose tolerance is normal.

M K Rhee1, D C Ziemer, P Kolm

  • 1Emory University School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Lipids, Atlanta, GA 30303, USA. mrhee@emory.edu

Diabetic Medicine : a Journal of the British Diabetic Association
|October 24, 2006
PubMed
Summary

Aging is linked to higher 1-hour post-oral glucose challenge (1-h OGTT) glucose levels, even with normal glucose tolerance (NGT). This age-related glucose handling impairment may increase cardiovascular disease risk.

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Area of Science:

  • Endocrinology
  • Gerontology
  • Metabolic Health

Background:

  • Aging is a significant risk factor for type 2 diabetes and cardiovascular disease.
  • Elevated glucose levels post-oral glucose challenge are indicative of impaired glucose metabolism.
  • Understanding glucose dynamics in aging populations is crucial for early risk assessment.

Purpose of the Study:

  • To investigate the association between age and 1-hour post-oral glucose challenge (1-h OGTT) glucose concentrations.
  • To determine if this association persists in individuals with normal glucose tolerance (NGT).

Main Methods:

  • Cross-sectional study utilizing the NHANES II database.
  • Analysis of 2591 subjects with NGT and documented 1-h OGTT.
  • Multivariable linear regression to assess the relationship between age and 1-h OGTT glucose.

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Main Results:

  • Each 10-year increase in age was associated with a 0.20 mmol/l rise in 1-h OGTT glucose (P < 0.0001).
  • A significant interaction between age and gender was observed, with faster glucose rise in men.
  • The effect of age on 1-h OGTT glucose was independent of fasting and 2-h OGTT glucose levels.

Conclusions:

  • 1-h OGTT glucose concentrations increase with age, even in individuals with NGT.
  • This age-related impairment in glucose handling warrants further investigation for its pathophysiological significance.
  • Such findings may indicate an elevated cardiovascular disease risk in aging individuals, irrespective of diabetes or prediabetes diagnosis.