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Elevation of serum high-mobility group box 1 protein during granulocyte colony-stimulating factor-induced peripheral

Kozo Tagami1, Toshiaki Yujiri, Atsuko Tanimura

  • 1Third Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan.

British Journal of Haematology
|October 24, 2006
PubMed

High mobility group box 1 (HMGB1) is a non-histone protein involved in maintaining the architecture of chromatin. HMGB1 also acts extracellularly as a cytokine, in processes such as inflammation, cell migration and stem cell recruitment. The involvement of HMGB1 in granulocyte colony-stimulating factor (G-CSF)-induced mobilisation of haematopoietic stem cells was investigated in 21 healthy donors. G-CSF treatment significantly elevated serum HMGB1 levels, which increased from 1.16 +/- 0.86 ng/ml, before treatment, to 31.1 +/- 5.99 ng/ml, after treatment. These findings suggest HMGB1 may play a role during the mobilisation of stem cells from the bone marrow into the systemic circulation.

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