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[Genetic regulatory pathway of gene related breast cancer metastasis: primary study by linear differential model and
Bao-cun Sun1, Chun-sheng Ni, Yu-mei Feng
1Cancer Institute and Cancer Hospital, Tianjin Medical University, Tianjin 300060, China.
Objective:
To investigate the potential genetic regulatory pathway of gene related breast cancer metastasis.
Methods:
Microarray technique was used to identify the gene expression profile and to screen the differential expression genes in breast cancer with special emphasis on the metastasis factors. A gene chip was available, obtained from the surgical samples, including breast cancer primary tissues and metastasis tissues, of 30 female patients with breast cancer at different clinical stages. Then potential genetic regulatory pathway of gene related breast cancer metastasis was analyzed with a linear differential model and k-means clustering.
Results:
Twenty-seven differential expression genes were identified. It was suggested that the potential regulatory pathway of gene related to breast cancer metastasis is made up of GRP, BPAG1, and SFRP2 genes.
Conclusion:
The metastasis of breast cancer is related to the cancerization caused by the abnormal expression of multiple genes. It is reliable to analyze the Genetic regulatory pathway of gene related breast cancer metastasis by using multiple bio-informatic measures.
