Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Data analysis of alternative splicing microarrays.

Miroslava Cuperlovic-Culf1, Nabil Belacel, Adrian S Culf

  • 1Atlantic Cancer Research Institute, 35 Providence Street, Moncton, NB E1C 8X3, Canada. miroslavac@health.nb.ca

Drug Discovery Today
|October 24, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unbiased distance correlation with sample-size-aware confidence bounds for comparative omics network analysis.

Frontiers in bioinformatics·2026
Same author

Pairwise causal discovery in biochemical networks: A survey on directionality inference within complex networks from stationary observations.

PloS one·2026
Same author

Functional and metabolomic analyses of brown adipose tissue during cold-deacclimation reveal rapid N-acetylated amino acid adaptations.

iScience·2026
Same author

Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential.

npj aging·2026
Same author

Foundations for AI-assisted Adverse Outcome Pathways (AOPs) in radiation research.

International journal of radiation biology·2026
Same author

Integrated bioinformatic and in vivo analysis confirms the cardioprotective role of OPA1.

BMC cardiovascular disorders·2025
Same journal

IdopNetworks: How to infer the individualized genetic architecture of genomics for precision medicine.

Drug discovery today·2026
Same journal

Organoid-AI platforms need integrated governance in drug discovery.

Drug discovery today·2026
Same journal

Inorganic nanoparticles for diagnostics, drug delivery and therapy for solid tumors.

Drug discovery today·2026
Same journal

HDAC11 as a potential therapeutic target for Alzheimer's disease.

Drug discovery today·2026
Same journal

From biologics to small-molecule modulators: The evolving landscape of interleukin-targeted therapeutics.

Drug discovery today·2026
Same journal

Targeting the GLP-1 receptor pathways for dual management of obesity and depression.

Drug discovery today·2026
See all related articles

Alternative splicing is crucial for drug and biomarker discovery. High-throughput studies and novel microarray analysis methods are advancing the identification and quantification of mRNA isoforms.

Area of Science:

  • Molecular Biology
  • Genomics
  • Biotechnology

Background:

  • Alternative splicing plays a key role in understanding drug and biomarker discovery.
  • Identifying, detecting, and quantifying mRNA isoforms across various tissues and conditions is challenging for most genes.
  • There is a growing emphasis on high-throughput studies of alternative splicing in drug and biomarker development.

Purpose of the Study:

  • To highlight the significance of alternative splicing in drug and biomarker discovery using gene examples.
  • To discuss the challenges in isoform identification, detection, and quantification.
  • To explore the advancements in high-throughput alternative splicing analysis and novel methods.

Main Methods:

  • Review of existing literature and case studies on alternative splicing.

Related Experiment Videos

  • Analysis of strategies for parallel analysis of alternative splicing using microarrays.
  • Exploration of novel analytical methods driven by microarray design.

    • Main Results:

    • Several example genes illustrate the importance of alternative splicing in discovery.
    • High-throughput studies are becoming central to alternative splicing research.
    • Novel analytical methods are emerging, spurred by alternative splicing microarray technologies.

    Conclusions:

    • Alternative splicing is a critical area for advancing drug and biomarker discovery.
    • Overcoming challenges in isoform quantification is essential for progress.
    • Microarray technologies and associated analytical methods are key enablers for future research.