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Updated: Jul 5, 2026

Preparation of the Mgm101 Recombination Protein by MBP-based Tagging Strategy
Published on: June 25, 2013
Do sigma factors need help with a meltdown?
Ruth M Saecker1, Caroline A Davis, M T Record
1Department of Chemistry, University of Wisconsin-Madison, 53706, USA. rmsaecker@wisc.edu
Abstract:
In this issue of Cell, Hsu et al. (2006) report on the binding activity of a variant of the bacterial transcriptional specificity factor sigma (sigma) to promoter DNA. This study demonstrates that the sigma variant induces a large distortion in the transcriptional start site in the absence of core RNA polymerase, raising intriguing new questions about the roles of sigma and core RNA polymerase in transcription initiation.
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