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Related Experiment Video

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Use of In Vivo Imaging to Screen for Morphogenesis Phenotypes in Candida albicans Mutant Strains During Active Infection in a Mammalian Host
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Morphogenesis and cell cycle progression in Candida albicans.

Judith Berman1

  • 1Department of Genetics, Cell Biology and Development, 6-160 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, MN 55455, USA. jberman@umn.edu

Current Opinion in Microbiology
|October 24, 2006
PubMed
Summary

Candida albicans exhibits distinct growth modes (yeast, pseudohyphae, hyphae) with unique cell cycle dynamics. Understanding these fungal morphogenesis and cell cycle connections is crucial for pathogen control.

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Area of Science:

  • Microbiology
  • Cell Biology
  • Mycology

Background:

  • Candida albicans, an opportunistic pathogen, exhibits yeast, pseudohyphae, and true hyphae morphologies.
  • These growth forms differ in morphology and cell cycle progression, impacting pathogenicity.

Purpose of the Study:

  • To investigate the relationship between cell cycle progression and morphogenesis in Candida albicans.
  • To elucidate the roles of specific organelles and cyclins in regulating these processes.

Main Methods:

  • Comparative analysis of cell cycle events and growth patterns across different Candida albicans morphologies.
  • Examination of the Spitzenkörper and polarisome functions in hyphal and yeast/pseudohyphae growth, respectively.

Main Results:

  • In hyphal cells, polarized growth is uncoupled from other cell cycle events.
  • Yeast and pseudohyphae show cell cycle-dependent polarized growth mediated by the polarisome.
  • Specific cyclins regulate morphogenesis and cell cycle progression, with some acting uniquely in yeast or hyphal cells.

Conclusions:

  • Morphogenesis and cell cycle progression in Candida albicans are intricately linked and regulated by distinct mechanisms.
  • Further research into cell cycle checkpoints is needed to fully understand the connection between morphogenesis and cell cycle progression.