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Updated: Jul 19, 2026
09:25
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Stem cells: tissue regeneration and cancer
Monika Tataria1, Scott V Perryman, Karl G Sylvester
1Department of Surgery, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, California 94305, USA.
Seminars in Pediatric Surgery
|October 24, 2006
Summary
Stem cells are key to regenerative medicine for tissue repair. Understanding stem cell biology, including cancer stem cells, is crucial for developing new therapies for diseases.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
- Cancer Therapeutics
Background:
- Regenerative medicine aims to replace or repair damaged tissues.
- Stem cells are fundamental to organ development and tissue regeneration.
- Consistent molecular mechanisms guide organ development and tissue repair.
Purpose of the Study:
- To review the clinical promise of regenerative medicine technologies.
- To examine the emerging concept of cancer stem cells.
- To highlight the importance of stem cell biology for understanding disease and therapy.
Main Methods:
- Review of current literature on stem cell biology.
- Examination of the stem cell hierarchy model in tissue development and repair.
- Exploration of the extension of this model to tissue carcinogenesis.
Main Results:
- Stem cells possess unique capabilities applicable to regenerative medicine.
- The stem cell hierarchy model explains tissue development, maintenance, and repair.
- The concept of cancer stem cells offers a new perspective on cancer therapeutics.
Conclusions:
- Stem cell biology is paramount for advancing regenerative medicine.
- Understanding cancer stem cells may revolutionize cancer treatment strategies.
- This field holds significant potential for clinical applications in various diseases.
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
01:23Tissue Renewal without Stem Cells
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
01:17Stem Cell Culture
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
01:19Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
01:22iPS Cell Differentiation
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
01:18Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...