Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronotherapy using corticosteroids for multiple sclerosis relapses.

Lea Glass-Marmor1, Tamar Paperna, Yaara Ben-Yosef

  • 1Division of Neuroimmunology, Multiple Sclerosis Center, Carmel Medical Center, 7 Michal Street, Haifa 34362, Israel.

Journal of Neurology, Neurosurgery, and Psychiatry
|October 24, 2006
PubMed
Summary

Night-time administration of intravenous corticosteroids significantly improved recovery and reduced side effects for acute multiple sclerosis relapses. Most patients preferred this chronotherapy approach, suggesting its potential benefit.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aging with multiple sclerosis and associated prevalence, incidence, comorbidities and healthcare utilization patterns in a population based study.

Scientific reports·2026
Same author

Corrigendum to "Glutaminase deficiency provides insight to the role of glutamine accumulation and neurotoxicity" [Mol. Genet. Metab. 148(2) (2026) 109906].

Molecular genetics and metabolism·2026
Same author

Immunotherapy-Mediated Modulation of the Gut Microbiota in Multiple Sclerosis: The Effects of High-Efficacy (Cladribine) and Moderate-Efficacy (Interferon Beta-1a) Treatments.

International journal of molecular sciences·2026
Same author

Erratum to "Glutaminase deficiency provides insight to the role of glutamine accumulation and neurotoxicity" [Mol Genet Metab. (2026) Vol. 148 Issue 2 109906].

Molecular genetics and metabolism·2026
Same author

Glutaminase deficiency provides insight to the role of glutamine accumulation and neurotoxicity.

Molecular genetics and metabolism·2026
Same author

Impact of Rapid Exome Sequencing on Pediatric Patients With Cardiomyopathy and Acute Heart Failure.

American journal of medical genetics. Part A·2026

Area of Science:

  • Immunology
  • Neurology
  • Chronobiology

Background:

  • Immune system activity exhibits a circadian rhythm.
  • Chronotherapy, aligning treatments with diurnal rhythms, can enhance drug efficacy and safety in immune-related diseases.

Purpose of the Study:

  • To compare outcomes of daytime versus night-time intravenous corticosteroid administration for acute multiple sclerosis relapses.

Main Methods:

  • 17 patients with multiple sclerosis were enrolled.
  • Clinical disability was assessed at baseline, day 7, and day 30.
  • Adverse events and patient preference for treatment timing were recorded.

Main Results:

  • Night-time corticosteroid treatment significantly improved clinical recovery (p<0.001).

Related Experiment Videos

  • Significantly fewer side effects were observed with night-time administration (p=0.007).
  • A majority of patients preferred night-time over daytime treatment.

    • Conclusions:

    • Chronotherapy with steroid treatment shows potential benefits for acute multiple sclerosis relapses.
    • This approach may also be beneficial for other immune-mediated disorders.