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Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
Published on: January 24, 2018
MPCD: a new interactive on-line crystallization data bank for screening strategies
Mathieu Charles1, Stéphane Veesler, Françoise Bonneté
1CRMCN-CNRS-UPR 7251, Campus de Luminy, Case 913, 13288 Marseille CEDEX 09, France.
Acta Crystallographica. Section D, Biological Crystallography
|October 24, 2006
Summary
The Marseille Protein Crystallization Database (MPCD) offers a new, free online resource for structural biology. It provides detailed crystallization data for macromolecules, aiding researchers in structure determination and biomaterial design.
Area of Science:
- Structural Biology
- Biochemistry
- Crystallography
Background:
- Protein crystallization is crucial for determining macromolecular structures.
- Existing databases like BMCD and CYCLOP contain valuable crystallization data.
- A centralized, accessible resource is needed to streamline crystallization research.
Purpose of the Study:
- To introduce the Marseille Protein Crystallization Database (MPCD) as a novel online resource.
- To consolidate and present protein crystallization information in an accessible format.
- To facilitate protein structure determination and biomaterial research.
Main Methods:
- MPCD aggregates data from BMCD and CYCLOP.
- Information includes macromolecule details, crystallization conditions, methods, and additives.
- Data is presented in an easily comparable table format.
Main Results:
- MPCD is freely accessible online.
- The database allows users to select crystallization parameters and generate analysis tables.
- Users can contribute new protein and crystallization data.
Conclusions:
- MPCD serves as an essential tool for crystal growers and researchers in structural biology.
- Integration with the Protein Data Bank enhances its utility for crystallogenesis.
- The database supports the design of structurally distinct molecules and assemblies.
