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Updated: Jul 19, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
A module map showing interaction between apolipoprotein E and phospholipase A2 polymorphism in lipid profiles
For-Wey Lung1, Wei-Tsung Kao, Bih-Ching Shu
1Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung, Taiwan. forwey@seed.net.tw
Objective:
Establish a possible conceptual relationship among Apo E and PLA2 polymorphism and lipid profiles.
Methods:
Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E and PLA2 polymorphisms and lipid profiles. Two hundred fifty-six participants agreed to have venous blood drawn for DNA studies.
Results:
By multiple linear regression, the PLA2 A2 allele showed a statistically significant influence on LDL-C (p = 0.0097), and the Apo epsilon2 allele showed a statistically significant influence on HDL-C (p = 0.0004), however, the interaction between the PLA2 A2 allele and the Apo epsilon2 allele was found to be significant in the blood fraction of HDL-C (p = 0.0388) and LDL-C (p = 0.0002). Decreasing HDL-C and increasing LDL-C were found when the PLA2 A2 and Apo epsilon2 allele co-existed.
Conclusion:
The presence of a physiologic balance contributes significantly to homeostatic and compensatory responses regulating blood HDL-C and LDL-C profiles. A module map of the generation-control cycle and conditional activity among Apo E, PLA2, and lipid levels is presented, and both behaviours and biological perspectives under the consilience model may suggest a new approach to many kinds of complex disorders.
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