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Updated: Jul 19, 2026

Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy
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Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy

Published on: April 9, 2017

Evidence that corticotropin-releasing factor receptor type 1 couples to Gs- and Gi-proteins through different

H Berger1, N Heinrich, D Wietfeld

  • 1Department of Peptide Chemistry/Biochemistry, Leibniz Institute of Molecular Pharmacology, Berlin, Germany.

British Journal of Pharmacology
|October 24, 2006
PubMed
Abstract

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G-protein Coupled Receptors

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G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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G Protein-coupled Receptors01:15

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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Two...