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Published on: May 26, 2015
High dose of amiodarone in a short-term period reduces the incidence of postoperative atrial fibrillation and atrial
Rafael Vieira Alcalde1, João Carlos Guaragna, Luiz Carlos Bodanese
1Hospital São Lucas da PUCRS e Programa de Pós-Graduação da Fundação Universitária de Cardiologia, Porto Alegre, RS, Brazil. alcalde@cardiol.br
Objective:
To investigate whether oral amiodarone administered before surgery for a short period in high dose would reduce the incidence of postoperative atrial fibrillation or atrial flutter and reduces the length of hospital stay.
Methods:
In the double-blind, randomized study, 93 patients were given either oral amiodarone (46 patients) or placebo (47 patients). Therapy consisted of 600 mg of amiodarone three times a day, started at minimum 30 hours and at maximum 56 hours before surgery.
Results:
Postoperative atrial fibrillation or atrial flutter occurred in 8 of 46 patients in the amiodarone group (17.4%) and 19 of the 47 patients in the placebo group (40.4%) (p=0.027). The mean dose of amiodarone was 2.8 g. Patients in the amiodarone group were hospitalized for 8.9+/-3.1 days and patients in the placebo group were hospitalized for 11.4+/-8.7 days (p=0.07). The hospital length were significantly prolonged in patients who developed atrial arrhythmias after surgery, despite the treatment received.(p<0.001).
Conclusion:
This new alternative way of using amiodarone in high dose and in a short-term period before surgery reduce the incidence of postoperative atrial fibrillation or atrial flutter in coronary artery bypass graft surgery.
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