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A gas-inducible expression system in HEK.EBNA cells applied to controlled proliferation studies by expression of

Nicola Susann Werner1, Wilfried Weber, Martin Fussenegger

  • 1Novartis Institutes for BioMedical Research, Discovery Technologies/Biomolecules Production, WSJ 506.3.04, CH-4002 Basel, Switzerland.

Biotechnology and Bioengineering
|October 24, 2006
PubMed

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...