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Updated: Jul 19, 2026

Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo
Published on: July 8, 2025
[The noninvasive study of cerebral veins and dural sinuses: comparison of two MR angiography techniques]
A J Pérez1, L C Hernández, M Ornia
1Servicio de Radiodiagnóstico, Hospital de Cabueñes, Gijón, Asturias, España.
Objective:
To evaluate MR venography with bolus injection of intravenous contrast and elliptical filling of the K space, using three-dimensional fast spoiled gradient-echo (3D-FSPGR) sequences, and to compare it to the technique most frequently employed in the study of cerebral veins and dural sinuses, which is two-dimensional time-of-flight (2D-TOF) MR venography.
Material And Methods:
Source images, multiplanar reconstructions, and maximum intensity projections (MIP) were obtained using both 2D-TOF venography and contrasted-enhanced 3D-FSPGR venography in 20 healthy volunteers. Two radiologists independently evaluated both techniques for the visualization of twenty-one predefined venous structures, classifying the depiction as completely visible, partially visible, or not visible.
Results:
The predefined venous structures were completely visible in 795 of 840 (94.6%) of the evaluations of contrast-enhanced 3D-FSPGR images versus 682 of 840 (81.1%) evaluations of 2D-TOF venography images. In the major dural sinuses, visualization was complete in 99.4% of the readings of contrast-enhanced 3D-FSPGR images versus 81% in the readings of the 2D-TOF images.
Conclusion:
3D-FSPGR with elliptical filling of the K space and bolus injection of contrast material provides higher quality images of the intracranial venous system than those obtained using 2D-TOF sequences.
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