[Wheezing and cough related to congenital airway abnormalities in young infants]

M van Veen1, W A F Balemans, J A Schipper

  • 1St Antonius Ziekenhuis, afd Kindergeneeskunde, Nieuwegein. m.vanveen@erasmusmc.nl

Insights

Infantile wheezing unresponsive to bronchodilators may signal rare airway malformations. Early diagnosis of bronchomalacia and tracheomalacia is crucial for infants with persistent respiratory symptoms.

Area of Science:

  • Pediatric Pulmonology
  • Medical Imaging
  • Congenital Disorders

Background:

  • Broncho- and tracheomalacia are rare congenital airway disorders.
  • These conditions can present with persistent wheezing and coughing in infants.
  • Symptoms often mimic viral infections but are unresponsive to standard treatments.

Observation:

  • Two infants presented with severe, persistent wheezing and respiratory distress shortly after birth.
  • Diagnostic workup included chest X-ray, bronchoscopy, and CT angiogram.
  • Findings revealed isolated left main stem bronchus malacia in one infant and tracheomalacia due to aortic arch compression in the other.

Findings:

  • Bronchomalacia: Isolated malacia of the left main stem bronchus.
  • Tracheomalacia: Caused by extrinsic compression from a right descending aortic arch.
  • Both cases presented with severe respiratory distress unresponsive to bronchodilators.

Implications:

  • Airway malformations like bronchomalacia and tracheomalacia should be considered in infants with unexplained, persistent respiratory symptoms.
  • Prompt diagnosis through bronchoscopy and imaging is vital for appropriate management.
  • Early identification can prevent severe respiratory distress and improve infant outcomes.

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